Abstract: Objective: To approach whether cytology may accurately subclassify Invasive lobular carcinoma of the breast in order to make cytological diagnosis significant. Methods : Nine hundred and twenty-six cases of fine needle aspirates cytological specimens of the breast were studied, 289 of which were breast cancer, including susceptible cases; among the 289 cases, 8 were diagnosed as invasive lobular carcinoma (ILC) by HE histological sections. Imaging analysis system was used to evaluate the cell morphology. Moreover, some aspects of ILC were compared with other types of breast cancer. Results : The incidence of ILC in breast cancer amounts to 2.8U (8/289). The cell morphology is anatomically and cytologically special for diagnosis. Compared to other types of breast cancer in the smear samples, there is no statistically significant difference (p>0.05). Conclusion : The subclassification of ILC can be made by fine needle aspiration in most of the cases. ILC may coexist with the invasive ductal carcinoma (IDC), so it must be prudential to subclassify further for the routine pathological diagnosis.