Abstract: Objective:To study the expressions of BRCA1 and p53 in epithelial ovarian cancer and their clinical significance. Methods: BRCA1 and p53 protein expressions were detected in 50 epithelial ovarian cancers.Kaplan-Meier method was used to analyze the relationship between their expressions and prognosis. Results: 1, The expression rate of BRCA1 was 30.0% in ovarian cancers,which was lower than that in benign tumor and normal ovary tissues significantly (P<0.01). And BRCA1 expression was correlated with pathological grade and pelvic lymph node metastasis.2,The expression rate of p53 was 64.0%, while the expression was negative in benign tumor and normal ovary tissues,and it related to pathological grade.3,There was negative correlation between the expressions of the two protein (P<0.01). 4, The mean survival time was longer in the patients with BRCA1 expression than those without. There was no effect of p53 on survival time. Conclusions: Down-regulation of BRCA1 gene in post-transcription plays a very important role in the occurrence and the development of ovarian cancer, and p53 gene maybe has a synergetic role with BRCA1 to promote tumor progression.