Abstract: Objective: To study the application and significance of intrapericardial vascular management and partial resection of left atrium in the operation of lung cancer. Methods： Lobectomy and pneumonectomy via intrapericardial management or combined with partial resection of left atrium were carried out in 141 patients with lung cancer. Results： The incidence of complications in postoperation was 36.88H,The operation mortality was 1.42H,the 1,3 and 5-year survival rates were 74.47%, 40.43H and 21.28%, respectively. Conclusions： The method of lobectomy and pneumonectomy via intrapericardial management or combined with partial resection of left atrium was secure,though the incidence of complications in postperation rose, but the close and long-term operation mortality hadn't changed. This method can increase the opportunity of operation, amplify the range of resection and reduce the incidence of surgical exploration.