Abstract: Objective: To investigate the relation between proximal subtotal gastrectomy for cardiac cancer undergoing stapled anastomosis and gastroesophageal reflux (GER). Methods： Thirty patients were measured by using SG-Ⅱcomputer manometer. Sixteen cases were studied by 24-h pH esophageal monitoring. Twelve cases were examined by endoscopy and pathological examination. Re-sults： Resting pressure above the esophago-gastric anastomisis was higher than that under the esopha-go-gastric anastomosis. Twenty-four hour pH monitoring demonstrated that GER. Abnomalities were found in 83.3P of patients through endoscopy and pathological examination. Conclusions: GER exists in the patients after proximal subtotal gastrectomy and esophagogastrostomy for cardiac cancer. The occurrence of GER with stapled anastomosis are similar to manual anastomosis. The occurrence of GER is not affected by the length of postoperative period. Twenty-four hour pH monitoring is the most reliable method for detecting GER. Sleep in semireclining position is an effective method of preventing GER in postoperative patients. It is important that treatments of GER are mainly prokinetics and mucosal coating agents.