Abstract: Objective: To observe the efficacy and toxicity of Oxaliplantin in treatment of the advanced colon carcinoma. Methods : Fifity-one patients were enrolled into the study and were divided into two groups. The twenty-six patients of group A (the treatment group) were treated with Oxaliplatin 130mg/m² on day 1, CF 200mg/m² on day 1-5, and FUDR 400mg/m² on day 1-5, respectively. There were 21 days in one cycle. The twenty-five patients of group 2 (the control group) were treated with CF 200mg/m² on day 1-5 and FUDR 400mg/m² on day 1-5 also, and there were 21 days in one cycle, too. The efficacy was evaluated two weeks after administration. Results : The efficacy of group A was 46.2%, and the main side-effects were sensory neurotoxicity, nansea, vomiting and drop of white blood cells. The effective rate in group B was 12% and the side-effects were nausea and vomiting, without neurotoxicity. Conclusion : The efficacy of the Oxaliplatin combined with the CF and FUDR in treatment of the advanced colon cancer was better than that of CF and FUDR. only. The patients can tolerate the side-effects well, so it's feasible in clinical treatment.