Abstract: Objective: To evaluate the effectiveness and safety of the chemoembolization treatment with HCPT combining with THP for hepatocellular carcinoma. Methods : Total 302 cases of hepatocellular carcinoma were included in this study. The age of the patients ranged from 24-70 yr (mean 54.8), and the size of the tumors were 21-144mm (mean 69mm). All patients received 1-5 series of TACE respectively. Therapeutic agents include: THP 40-60mg, HCPT20mg, 5-FU 750- 1000mg, Lip 5-20ml. The radiological and laboratory tests, as well as the side-effects and survival rate were analysed, respectively. Results : The duration of follow-up was 6-22m (mean 14.2m), and the response rate was 61.6Y. The survival rates of the first and second years were 57.3Y and 27.8Y, respectively. The main complications included myelosuppression (grade I-III) and symptoms of alimentary tract (grade I-II). Conclusion : Combination of HCPT and THP in treating hepatocellular carcinoma is reliable and effective. Long-term observation is needed in the future.