杨文国, 王海云, 唐雷杰, 程康. 非小细胞肺癌318例放疗效果的临床因素分析[J]. 中国肿瘤临床, 2005, 32(1): 40-42.
引用本文: 杨文国, 王海云, 唐雷杰, 程康. 非小细胞肺癌318例放疗效果的临床因素分析[J]. 中国肿瘤临床, 2005, 32(1): 40-42.
Yang Wenguo, Wang Haiyun, Tang Leijie, Cheng Kang. Clinical Factor Analysis of Radiotherapy Effect for 318 Patients with Non-small Cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(1): 40-42.
Citation: Yang Wenguo, Wang Haiyun, Tang Leijie, Cheng Kang. Clinical Factor Analysis of Radiotherapy Effect for 318 Patients with Non-small Cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(1): 40-42.

非小细胞肺癌318例放疗效果的临床因素分析

Clinical Factor Analysis of Radiotherapy Effect for 318 Patients with Non-small Cell Lung Cancer

  • 摘要: 目的:探讨非小细胞肺癌单纯放疗的生存情况及影响预后的临床因素。方法:回顾性分析1990年1月至1997年12月收治的318例非小细胞肺癌,Ⅰ期12例,Ⅱ期71例,ⅢA期158,ⅢB期77例,均经病理或细胞学证实。采用60CO机照射,常规分割,周剂量10~12.5Gy。有49例放疗开始到半量时按治疗计划布野,全程包括原发灶及纵膈,纵膈剂量大于57Gy。其它病例纵膈剂量40Gy,生存率计算采用Kaplan-Meier法及Log-rank检验。结果:全组中位生存期10个月,1、3、5年生存率分别为43%、15%和9%。影响生存的临床因素分析结果表明,临床分期,近期疗效周剂量与预后有密切关系(P<0.05),而放疗总剂量和纵膈剂量与预后未见明显关系(P>0.05)。结论:影响肺癌患者放疗预后的临床因素,主要是临床分期、近期疗效和周剂量的大小,而放疗总剂量和纵膈剂量高低与生存率无明显关系。

     

    Abstract: Objective:To analyze the survival results of the patients with non-small cell lung cancer (NSCLC) treated by radiotherapy alone and the clinical factors affecting the survival results. Methods: Three hundred and eighten patients with NSCLC at the periodfrom January, 1990 to December,1997 were included in this study (stag I, 12 cases; stageII, 71 ctage, IIIA, 158 cases; stage IIIB, 77 cases). All patients were confirmed by pathology and they were treated by cabalt-60 conventionally fractionated, with weekly dose 10一12.SGy. In 49 cases of patients, the treatment planning system was used at the period from the beginning to the semis of radiotherapy, and the primary lesion and medi- astinum were included in the full course of radiotherapy. The irradiation dose on mediastinum was more than 57Gy. For the rest of patients, the mediastinal dose was 40Gy. The survival rate was analyzed by determination of Kaplan-Meier and Log-rank. Results: The median survival for whole group was 10 months. The 1, 3 and 5-year survival rate were 43%, 15% and 9%, respectively. The earlier the clinical stage, the better the prognosis (P=0.0001). The survival rate of the patients with complete remission at the end of radiotherapy was better that of the patients with residual tumor (P=0.0001). The survival of the patients with weekly dose larger than lOGy was better compared to other dose groups (P=0.0461). There was no relationship among the survival rate, the dose and the mediastinal dose. Conclusion: The results show the survival rate of the patient with NSCLC treated by radiotherapy alone is related to the clinical stage, instant response and weekly dose, but not to the total dose and the mediastinal dose.

     

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