Abstract:
Objective : To investigate the correlation between macrophages and VEGFR-3 positive vessel density in uterine cervical cancers and their relationship with lymphatic metastasis.
Methods : The CD68 and VEGFR-3 were identified by immunohistochemically in the 59 parafin specimens respectively. The density of VEGFR-3 positive vessel was assessed quantitatively by Computer-assisted video analysis system.
Results : The mean macrophage counts and VEGFR-3 positive vessel density were significantly higher in the lymph node metastasis group than in the non-metastasis group (P<0.05,P<0.01). The mean macrophage counts and VEGFR-3 positive vessel density did not correlated with tumor stage and clinical stage. A positive correlation was found between the mean macrophage counts and VEGFR-3 positive vessel density in tumors (P=0.014).
Conclusion : Macrophages infiltration triggers lymphatic angiogenesis in cervical cancers, which may be closely related to lymph node metastasis.