Abstract: Objective : To investigate the relationship between the expression of p73, FHIT and PTEN protein and the significance of p73, FHIT and PTEN gene in lung cancer. Methods : The expression of p73, FHIT and PTEN protein in 65 cases of lung cancer, adjacent tissues of cancer and normal tissues was tested by immunohistochemical SABC method. Results : The rate of expression of p73 protein in tumor tissues was significantly higher than that in adjacent tissues of cancer and normal tissues(P<0.05), but the rate of expression of FHIT and PTEN protein in tumor tissues was significantly lower than that in the adjacent tissues of cancer and normal tissues (P<0.05). It was shown that p73, FHIT and PTEN protein expression did significantly not correlate with the type and grade of the tumor(P>0.05),but it correlated with the clinical stage and survival time of the patients (P<0.05). Conclusion : The results suggest that p73 gene should not play main role of action in restraining lung carcinoma. but FHIT and PTET gene should play the main role of action in restraining lung carcinoma. The expression of p73、FHIT and PTEN protein should be used as an useful marker of the biological behavior of lung cancer and as an independent prognosis factor for the patients with lung cancer.