Abstract: Objective : To detect the surgical treatment effects for patients with colorectal gastrointestinal stromal tumors (GISTs) and its influential factors. Methods : In the retrospective study, the clinical data and the tissue slices including immunohistochemical staiming of 19 patients with colorectal GISTs from Jan 1990 to Mar 2004 were rechecked, and all patients were followed up carefully. More attention was paid to the surgical treatment effects and the influential factors of survival after operation. Results : The 1, 3 and 5-year overall survival rates for 18 patients with the total resection of tumor were 100%,79.3% and 69.4%, respectively. The median survival duration for 18 patients was 60.0 months. The 3 and 5-year survival rates for the patients with the non-extended resection of tumor were 72.9% and 48.6%, but the survival rates at 3 and 5-year were 85.7% for the patients with tumor extended resected. Tumor size, pathological type, karyokinesis and recurrence-metastasis were related with survival rates for the patients with tumor resected completely in monovariate analysis, but only tumor size, karyokinesis, recurrence and metastasis were related with survival rates by the COX Regression multivariate analysis (P<0.05). Conclusion : Surgery is still the main treatment for colorectal GISTs. Local complete resection is the principal treatment.