Abstract: Objective :To discuss the methodology and efficacy of percutaneous vertebroplasty combined with radiotherapy for the treatment of spinal vertebra metastases. Methods :Twenty-six pabents underwent percutaneous vertebroplasty on fouty-two segment levels with DSA guidance, bone cement was made accoding to the ratio power/liquid/contrast as 3:2:1 in injecting paste form. The puncturation through pedicle of vertebral arch and lateral posterior body of vertebra was both adopted in thoracic and lumbosacral vertebrae site. After making sure that the puncture was completed and there was no leakage in vertebral lx >dy, the lx >ne cement was poured into vertebral lx >d y quickly. The average priming volume of thoracic spine was 4.6m1, the lumbar spine was 5.4m1 and the sacral spine S.SmI. The easement of pain was observed and CT scaning was carried out on the day and one month laterter operation. Radiotherapy was performed 3-4 days after PVP with external radiation of 6 for 3-4Gy one fraction to a total dose 35-45Gy/3-4 weeks. Results :The successful puncture of PVP was ob- tamed in 100%. The leakage of bone cement occurred in 2 cases by CT scaning, but no clinical tomplaint was found. Radiotherapy was performed successfully in 24 patients. The rate of pain relief was 80.8% (21/26) after PVP, and it increased to 96.2% (25/26) when combined with radiotherapy. The follow-up was from 4 10 months and the rate of pain relief reached 88.5%(23/26) in 10 months. Conclusions : Percutaneous vertebroplasty can strengthen the target and relief pain quickly. It can guarantee the feasibility and safty of radiotherapy sequent in the treatment of intensive patient. Radiotherapy strengthen the inhibition of tumor, so as to increase therapeutic effect.