Abstract: Objective :To evaluate the prognostic value of the CIA-19mRNA in the peripheral blood of patients with breast cancer. Methods : Expression of CI19mRNA in the peripheral blood in 86 breast cancer patients was determined by reverse transcription polymerase chain reaction (RT-PCR).And immunohistochemical evaluation was used to determine the expression of c-erbB-2, ER, PR protein in breast cancer tissue samples. Results :1) The positive rate of CIA-19mRNA in the peripheral blood of patients with breast cancer were 52.3%.2) The expression of CIA-19mRNA in the peripheral blood after operation was significantly correlated with stage (P<0.05) and nc)relationship to axillary nodes, tumor size, c-erbB-2 and ER, PR protein. 3) There was significan relapse free survival (RFS) and overall survival difference between the positive patients and negative ones. Conclusions :Conclusion: Detection of CIA-19mRNA in the peripheral blood after operation is valuable for evaluating the prognosis of pabents with breast cancer.