Abstract: Objective :To explore the relationship between dynamic contrast enhanced MRI of early enhancement rate, enhancement pattern, metastases of axillary nodes and the microvascular density(MVD) in breast cancer. Methods :Dynamic contrast-enhanced MR imaging of breast was performed in 38 cases (31 cases were breast cancer verified by pathology). Early enhanced rate(OSI) and enhanced feature of breast cancer were studied on MR imaging. The MVD in both the center and the peripheral of the lesions were acquired through SP immunohistochemical technique. Metastases of axillary nodes were confirmed by pathology. Results : The study shows that the distribution of MVD was heterogeneous, and the OSI became higher and lower with the changes of MVD, showed closed association with MVD(r=0.882-0.886). In cases the greater MVD was most frequently observed at the marginal region of breast cancer (P<0.01), while the peripheral enhancement can be observed on MR imaging. In non-pe-ripheral-enhancement cases on MR, there was no significance difference in MVD between the center and the marginal. Higher incidence of metastases of axillary node was happened in peripheral -enhancement cases(72% 8/11) than in non-peripheral-enhancement cases(35% 7/20). (P<0.01). Conclusions : MR enhancement shows a high relativity with MVD, and as a noninvasive method, it has potential role in estimating the degree of agiogenesis of breast neoplasm.