Abstract: Objective : To evaluate the clinical management of cervical intraepithelial neoplasia Ⅲ(CIN Ⅲ) by comparative study on the results of pathological examination between colposcopic multiple biopsies and cervical conization specimens. Methods : A 3-year retrospective study was conducted in 153 patients with CIN Ⅲ. The correlation between colposcopic multiple biopsies and cervical conization specimens were analyzed. Results : In comparison with pathological examination results of biopsies with cervical conization, the correlation was accurate in 95 of 153 case(62.09%), but there was not correspondence in 58 of 153 case (37.91%). The colposcopic multiple biopsy was found to be more or less severe than cervical conization in 42 cases (27.45%) and 16 cases (10.46%) respectively. Uixteen cases with invasive cancer were missed at the time of colposcopy and biopsy but subsequently diagnosed by conization. Conclusion : There is a discrepancy between the result of pathological diagnosis for cervical conization and for colposcopic multiple biopsies. We suggest that patients with cervical conization be conducted on CIN Ⅲ for final diagnosis and treatment.