乙酰肝素酶mRNA在大肠癌中的表达及意义

The Expression and Significance of Heparanase mRNA in Colorectal Carcinoma

摘要: 目的: 探讨乙酰肝素酶在大肠癌中的表达及意义。 方法: 应用原位杂交方法检测乙酰肝素酶mRNA在45例大肠癌组织中的定位及表达。 结果: 45例大肠癌组织中,乙酰肝素酶mRNA阳性表达22例(48.88%)。26例大肠癌伴淋巴结转移者,其原发灶内乙酰肝素酶mRNA表达明显高于无转移组,有显著差异(P<0.01)。乙酰肝素酶mRNA表达与大肠癌组织浸润深度、淋巴结转移有关。 结论: 乙酰肝素酶可能在大肠癌的生长、浸润和转移中起一定的作用。

Abstract: Objective : To study the expression and role of heparanase mRNA in colorectal carcinoma. Methods : The expression of heparanase mRNA by ISH in 45 cases colorectal carcinoma was detected. Results : There were 22 cases with heparanase mRNA positive staining in 45 cases of colorectal carcinoma, the positive rate was 48.88%. The increased expression of heparanase mRNA was observed in 26 cases of colorectal carcinoma with lymph node metastasis compared to those without metastasis(P<0.01). Heparanase mRNA expression related to lymph node metastasis and depth of serosal invasion in colorectal carcinoma. Conclusion : Heparanase may play a definite role in the growth,invasion and metastasis in colorectal carcinoma.