Abstract: Objective : To explore an optimal method of promoting the curative effect and the quality of life through reviewing the responses, survival rate and side effect to chemoradiotherapy in 41 patients at our department, with Hodgkin's Lymphoma (HL), during 10 years. Methods : All patients with HL received multicycle chemotherapy and a followed-up radiation therapy with two different doses and fields. Results : The response rate of single cycle for the regime of ABVD, MOEP/ABY, COEP/BA-COP, CHOP and MOPP was 85.5%, 75.6%, 70.4%, 69.8% and 65.7%, respectively. For the two groups of patients receiving the involved -field radiotherapy and the extended -field radiotherapy alone, the clinical complete response (CR) rate was 82.3% and 83.3% respectively. The radiotherpy-related local fibrosis occurred in 15 cases(36.6%) and abnormality on electrocardiogram was found in 8(19.5%); hydropericardium and pleural effusion occurred in 4 cases and the second malignancy was observed in one case. The 5-year overall survival (OS) rate was 91.2% and 3-year OS rate was 94.9%. Conclusions : The A B V D regime is still the first choice of chemotherapy for the patients with HL; there is no statistical difference for the long-term effect of the treatment between the group with the 30Gy