130例晚期非小细胞肺癌的预后分析
Analysis for the Prognosis of 130 Patients with Advanced NSCLC
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摘要: 目的: 回顾分析130例晚期非小细胞肺癌(NSCLC)的预后因素,探讨化疗方案、疗程数、转移情况、治疗效果等因素对晚期非小细胞肺癌预后的影响,从而指导临床的个体化规范化治疗。 方法: 1996年1月至2003年12月130例经组织学或细胞学确诊的晚期非小细胞肺癌患者(Ⅲ期55例占42.3%,Ⅳ期75例占57.7%),至少接受1个周期化疗,观察生存期,分析影响预后的因素。 结果: COX比例风险模型分析显示化疗疗程数和化疗效果有独立预后作用。单因素分析显示,不同方案、不同的化疗疗程数直接影响疗效及生存时间。 结论: 晚期非小细胞肺癌的治疗应根据循证医学的原则给予有效的化疗方案和合适的疗程数。Abstract: Objective : To study the prognostic factors of 130 patients with advanced non -small cell lung cancer (NSCLC) for exploring the mode of individual treatment mode. Methods : From January 1996 to December 2003, survival rate of the patients with advanced NSCLC was observed and prognostic factors were analyzed using SPSS 8.0, after the diagnosis by histology or cytology and the staging by related exams. Results : COX multiple variable analysis showed that there was a prognostic significance in the number of chemotherapy cycles and the response rate (P<0.0001). Conclusion : The number and therapeutic effect of chemotherapy cycle affect the prognosis of advanced NSCLC patients.
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