Abstract: Objective : To evaluate relationship between C E A CA15-3 tumor labels repressitivity in serum and breast cancer. Methods : CEA CA15-3 level in 210 caces with breast cancer, 75 caces with benign breast tumor and 50 normar women were examined by particle immunofluorescence and the results were contrasted respectively. Results : Two labels increased significantly in 3-4 stage of breast cancer (P<0.005). There was not significant differences in benign tumor, normar tissue and 1-2 stage of breast cancer (P>0.05). Two tumor labels were relative to size of tumor and infiltration of lymph nodes,specially in the patients with more than 4 lymph nodes metastasis and remote metastasis (P<0.005). The labels were not relative to idiosyncrasy of tumor tissue (P>0.05). Dynamic observation after operation showed that CEA CA15-3 increased in the patients with remote metastasis, and CEA had not difference in the patients with regional recurrence (P>0.05), but CA15-3 had directive significance (P<0.005). Conclusion : CEA CA15-3 were not an ideal tumor labels in early stage of breast cancer, but which had an intimate relation with stage, metastasis of lymph node and remote metastasis in the patients.Therefore the tumor labels were an effective index for predicting metastasis before operation, monitoring recurrence after operation and evaluating prognosis.