Abstract: Objective : To evaluate the efficacy of Trolamine cream in the prevention and treatment of acute radioactive dermatitis in patients with nasopharyngeal carcinoma. Methods : From 2002 to 2004, Trolam ine cream was used in 125 cases with nasopharyngeal carcinoma, in com bination with radiotherapy, for prevention and treatment of acute radiation dermatitis, among which 37 cases were in the prevention group, 51 cases in the treatment group and 37 cases in the control group. Results : The results showed that in the prevention group, the rate of radioactive dermatitis at 20Gy was 29.7%(11/37), that in the treatm ent group and the control group was 70.6% (36/51) and 78.4%(29/37),respectively, P<0.05. The rate of radiation dermatitis of grade Ⅱ in the prevention and the treatment group was 27 L and 59%, respectively, as compared to 78 L in the control group (P<0.05). The meantime for curing radioactive dermatitis of grade Ⅱ in the prevention, treatment and control group was 5,9, and 13 days, respectively. Conclusion : Prophylactic application of Trolamine cream can postpone the development of radioactive dermatitis. Trolamine cream can lower acute radiation response in skin and hasten healing of acute radiation dermatitis.