曹卫国, 赵胜光, 许赪, 陈石磊, 车锦凤, 许福熙, 金冶宁. 早期隔上霍奇金淋巴瘤斗篷野与累及野放疗联合化疗比较[J]. 中国肿瘤临床, 2005, 32(16): 932-934.
引用本文: 曹卫国, 赵胜光, 许赪, 陈石磊, 车锦凤, 许福熙, 金冶宁. 早期隔上霍奇金淋巴瘤斗篷野与累及野放疗联合化疗比较[J]. 中国肿瘤临床, 2005, 32(16): 932-934.
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Cao Wei-guo, Zhao Sheng-guang, Xu Cheng, . Comparison between Mantle Field Radiotherapy and Involved Field Radiotherapy Combined with Chemotherapy in Patients with Early Supradiaphragmatic Hodgkin's Lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(16): 932-934.
Citation: Cao Wei-guo, Zhao Sheng-guang, Xu Cheng, . Comparison between Mantle Field Radiotherapy and Involved Field Radiotherapy Combined with Chemotherapy in Patients with Early Supradiaphragmatic Hodgkin's Lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(16): 932-934.
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早期隔上霍奇金淋巴瘤斗篷野与累及野放疗联合化疗比较

Comparison between Mantle Field Radiotherapy and Involved Field Radiotherapy Combined with Chemotherapy in Patients with Early Supradiaphragmatic Hodgkin's Lymphoma

    摘要
  • 摘要: 目的:比较早期隔上霍奇金淋巴瘤(HD)斗篷野与累及野放疗联合化疗的疗效。方法:对35例早期HD患者,先予化疗4个疗程,然后随机分为常规斗篷野放疗(20例)或累及野放疗(15例),剂量为大野30Gy,局部肿块区加至40Gy,放疗后再化疗2个疗程。结果:中位随访58个月。3年总生存率为94.3%。无复发生存率为80.0%。两组3年总生存率及无复发生存率无明显差异。结论:早期隔上HD在化疗基础上,累及野与斗篷野放疗疗效相似,并发症较低。

     

    Abstract: Objective : To compare the efficacy between Mantle Field Radiotherapy and Involved Field Radiotherapy Combined with Chemotherapy in Patients with Early Supradiaphragmatic Hodgkin's Lymphoma (HL). Methods : Between 1996 and 2001, 35 patients with stageⅠ~Ⅱ HL were randomly assigned to receive radiotherapy of 30 Gy mantle field (EF) + 10Gy to bulky disease (20 cases) or 30Gy involve field (IF) + 10Gy to bulky disease (15cases). All patients received 6 cycles of chemotherapy before and after radiotherapy. Results : The median follow- up time was 58 months (range 36 115).Overall survival was 94.3%(33/35) and freedom from treatment failure was 80.0%(28/35) at three years.The three-year survival rate revealed no difference for arms EF (95.0%, 19/20) and arm IF (93.3%, 14/15), respectively. Conclusion : Radiotherapy volume size reduction from EF to IF after chemotherapy for four cycles produces similar results and less toxicity in patients with early - stage supradiaphragmatic HL.

     

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