Abstract:
Objective : To evaluate the effect of recent clinical trial and immune function of highly agglutinative staphylococcin combined radiotherapy in the treatment with nasopharyngeal carcinoma (NPC).
Methods : A total of 62 patients with nasopharyngeal carcinoma were randomly divided into two groups: the test group (n=32) and control group (n=30). The control group was treated with conventional radiotherapy. The test group was treated with the highly agglutinative staphylococcin combined with conventional radiotherapy.
Results : Highly agglutinative staphylococcin plus radiotherapy were beneficial to the nasopharyngeal control rate and the cervical lymph nodes control rate, but there was a significant difference in control rate between the two groups (P>0.05). The 1-, 3- and 5-year survival rates of test groups and control groups were 96.9% and 93.3%, 84.4% and 66.7%, 77.3% and 57.9%,(P>0.05) respectively. The recrudesce and distant metastases rates of test group and control group were 28.1% and 50.0%, (P>0.05) respectively. After treatment the NK of the test group is significant higher than the control group, P<0.01. After treatment the T lymphocyte subsets, CD
3, CD
4, CD
4/CD
8 of the test group were significantly higher compared to the control group, P<0.01.
Conclusion : Highly agglutinative staphylococcin plus radiotherapy are beneficial to the nasopharyngeal control rate and the cervical lymph nodes control rate, and it can advance cellular immune function in patients with NPC. It may lower the distant metastases in the patients.