Abstract: Objective: To study the expression of survivin, endoglin in the breast cancer and its relationship with angiogenesis and its significance. Methods: The expression of survivin, endoglin and apoptosis was detected in 100 cases of breast cancer,30 cases of hyperplasia mammary and 56 cases of the normal tissue by using immunohisochemical EnVision. Results: The positive rates of survivin were 3.6%、 6.7%、 76.0% in the normal tissue、hyperplasia mammary and breast cancer, the positive rates in the last groups was higher than those in the former two groups (P<0.005). The expression of survivin was correlated with lymph node metastasis although the difference is significant (P<0.05). The expression of survivin protein of high differentiation group, middle and low differentiation group were 35.0%,83.1% and 95.2%. The statistic between middle, low differentiation group and high differentiation group was different (P<0.005). The positive rates of endoglin were 0、 3.33%、 53.0% in the normal tissue、hyperplasia mammary and breast cancer, the positive rates in the last groups was higher than those in the former two groups (P<0.05); The expression of endoglin was correlated with lymph node metastasis although the difference is significant (P<0.05); MVD in both survivin and endoglin positive tumors was significant higher than in survivin and endoglin negative tumors(P<0.05); Significant relationship was found between survivin and endoglin(P<0.05). Conclusions: Experssion of survivin and endoglin expressed in breast cancer is upregulated and the two exert the synergy during the carcinogenesis and development of breast cancer as well as angiogenesis of the tumor.