Abstract: Objective: To explore the important role of VEGF and/or IL-6 in pathogenesis of the cervical cancer and to analyze the expression of VEGF and IL-6 using the quantitative analysis in variant cervical cancer. Methods: The expression of VEGF and IL-6 was detected by FCMin the tumorous tissues from 50 cervical cancer subjects and 10 normal cervical tissues. Results: The expression of VEGF was significantly higher in squamous cell carcinoma and adenocarcinoma than that in normal cervical tissues (P<0.01, P<0.01). Moreover, the expression of VEGF in adenocarcinoma and ≥ stage II was markedly higher than that in squamous cell carcinoma and ≤stage I (P<0.05, P<0.01), respectively. However, the expression of IL-6 was markedly increased in lymph node metastasis group and low histological differentiation group, compared to the lymph node non-metastasis group and high histological differentiation group (P<0.05, P<0.01), respectively. The expression was higher in the group of patients younger than 40, compared to the patients group with the age of 40 to 59 and over 60 respectively, which was also age-dependent (P<0.01, P<0.01). Conclusions: Both VEGF and IL-6 are involved in the pathogenesis of cervical cancer, and measurement of expression of VEGF and IL-6 may be developed as a means to evaluate the malignant degree and prognosis of cervical cancer.