痰脱落细胞hnRNPA2/B1检测对肺癌诊断价值的探讨

Investigation on the Value of hnRNP A2/B1 for Diagnosing Lung Cancer by Examination of Deciduous Epithelial Cells

摘要: 目的: 检测痰脱落细胞hnRNPA2/B1在肺癌诊断中的敏感性和特异性,探讨其对肺癌诊断价值。 方法: 采用免疫细胞化学染色方法,利用单克隆抗体检测临床可疑肺癌患者痰脱落细胞中hnRNPA2/B1的表达情况。 结果: 痰脱落细胞hnRNPA2/B1免疫细胞化学检查的敏感性为80.8%(21/26),特异性为78.9%(15/19),显著优于常规细胞学检查。 结论: hnRNPA2/B1检查敏感性、特异性高,可用于肺癌的辅助诊断。

Abstract: Objective :To detect the sensibitity and specificity of hnRNPA2/B1 in deciduous cellsin sputum sensibitity and specificity, in order to evaluate the value for diagnosing lung cancer. Methods :The expression of hnRNPA2/B1 was detected in deciduous cells in sputum from a group of clinical lung cancer-suspected patients by immunocytochemistry. Results :The sensibitity and specificity of hnRNP A2/B1 expression in deciduous cells of sputum were 80.8% (21/26) and 78.9% (15/19). It exceeded significantly the common cytologic examination. Conclusions :The sensibitity and specificity of hnRNP A2/B1 is high enough to be used in assisted diagnosis of lung cancer.