Abstract: objective : Observe the outcome of chemoradiotherapy combined with sipulin in the patients with high-risk breast cancer after the modified radical mastectomy and its affection to Karnofsky performance scale (KPS) and peripheral hemogram. Methods : 115 cases with high-risk breast cancer were randomized into two groups, one was study group with sipulin combined with chemoradiotherapy, another was control group only with chemoradiotherapy. 0bserve the affection to KPS, the peripheral hemogram and 5-year tumor free survival rate, local regional recurrence rate, distant metastasis rate. Results : The valure of KPS was lower in control group than that in study group after the treatment (P<0.05). The value of HB, WBC, RBC, PLT wasn't statistically different in study group before and after the treatment (P>0.05). But the value of which was statistically different between two groups after the treatment and in control group before and after the treatment. The 5-year tumor free survival rate were78.33%, 63.64% in study group and control group respectively (P>0.05), the local regional recurrence rate were10%,16.36% respectively (P<0.05), the distant metastasis rate were 11.67%, 20% respectively (P<0.05). Conclusions : Sipulin can improve life quality, promote peripheral hemogram and control the proliferation of the tumor cell.