Abstract: Objective: To study histopathologic features and immunophenotype of morphologic variants of DLBCL. Methods: A total of 108 cases with DLBCL were studied and immunohistochemical staining was carried out for CD10/bcl-6 in DLBCL tissue microarry. Results: Morphologic variants of the 108 cases were shown as follows: 89.9% centroblastic, 2.8% immunoblastic, 1.9% anaplastic large B-cell type, 1.9% T cell rich B cell type and 3.7% others. The cases with DLBCL indicated the rich reactive cell in 23.1%, fibrillary matrix in 41.7%, plasmacytic differentiation in 21.3%, rich blood vessel in 14.8%, signet ring cells in 14.8%, necrosis in 8.3%, eosinophils in 3.7% and bands of sclerosis in 3.7%. Fibrillary matrix and rich reactive cell were frequently seen in any of variants. CD10 and bcl-6 was positive in 44.2%, 48.1% of CB and in 2/2 cases with ALCL, respectively, but negative in 3/3 IB. Conclusions: DLBCL variants have similar and special histopsthology features of B cell lymphoma. CD10/BCL-6 expression pattern may be helpful in identifying main variants of DLBCL.