Abstract: Objective: To study the blood supply of primary liver cancer and evaluate the side effect of Portal Vein and Arterial Dual-Chemoembolization on it. Methods: Twenty-two subjects suffered large hepatocellular cancer were divided into two groups at random. The level of blood-routine, hepatic function, tumor size and of life quality were observed before and after the treatment. Results: The hepatic artery and portal vein were 100% successively reconstructed, Ⅳ-Ⅴgrade hepatic artery can be seen clearly. Combined with image from DSA, we find that hepatic artery surpply the center of the tumor,portal vein circumfuse the tumour; No significant differences were found in tumor sizes?the levels of WBC, TBil, ALT, life quality between the two groups (P0.05). Conclusion: MSCT can be used to restrict the hepatic artery and portal vein for primary liver cancers and no significant side-effect has been found from the people who accepted portal vein and arterial dual-chemoembolization therapy.