非小细胞肺癌7天连续加速放疗的Ⅰ期试验

The Research on Stage-Ⅰ Trial for 7-Day's Continuous Accelerated Irradiation of Non-small Cell Lung Cancer

摘要: 目的:探讨非小细胞肺癌(NSCLC)7天连续加速放疗(CAIR)的毒性反应及近期疗效。方法:对40例ⅢA～B期NSCLC病例,分别给予CAIR和常规放疗(CF)。结果:两组毒副反应无明显差异,P>0.05,近期疗效两组差别无显著性意义,P=0.065。结论:CAIR治疗NSCLC毒副反应可以耐受,疗效有待进一步观察。

Abstract: Objective: To discuss the local control rate, short-term curative effect and toxic reaction of NSCLC using the 7-day-a-week continuous accelerated irradiation (CAIR). Methods: Forty cases with local advanced stage (IIIa and b) NSCLC received CAIR and CF respectively. Results: There was neither overt difference in the side effect and toxicity, P=0.065, and was nor significance in short-term curative effect between the two arms P>0.05. Conclusion: The side effect and toxicity of the 7-day continuous accelerated irradiation on non-small cell lung cancer are endurable, and the curative effect needs further observation.