Abstract: Objective: To explore the correlation between the precancerous lesions of the breast and the early-stage breast cancer by a clinical point of view. Methods: The clinicopathological data were analyzed retrospectively for the pationts with nipple discharge and local thickening of glandular organ of the breast treated during January 1992 to December 2004 and for those with canceration of local thickening of glandular organ of the breast treated in recent 5 years. Results: Among the 252 cases of nipple discharge (without lumps), 31 were papillomatosis and epithelial hyperplasia, accounting for 12.3%, 22 breast cancer with a percentage of 8.7% and 3 papillomatosis developed into homonymous breast cancer 3 years later. Among 192 cases with local thickening of glandular organ of the breast, 23 were papillomatosis and epithelial hyperplasia (12%) and 19 were breast cancer (9.9%). A total of 52 cases were canceration of local thickening of glandular organ of the breast, accounting for 5.16% (52/ 1008) that the breast cancer treated at the same period. Conclusion: Nipple discharge and local thickening of glandular organ of the breast can not only be the precancerous lesions but also the important physical signs of the early-stage breast cancer.