Abstract: Objective: To evaluate the three-dimensional conformal radiation therapy (3DCRT) with concurrent chemotherapy for recurrent carcinoma of the cervix. Methods: A total of 30 patients were divided into 2 groups: 13 patients with failure after radiotherapy, doses of 3DCRT for relapse at pelvis were 20 to 40Gy and 60 to 70Gy for distant failure (para-aortic lymph nodes); 17 patients with failure after radical surgery, conventionally radiated 40 to 45Gy for pelvis and 3DCRT 25 to 30Gy for tumor site in patients with pelvic relapse, 3DCRT 60~70Gy for patients with para-aortic metastases. Concurrent chemotherapy with cisplatin 30mg D1 to D4 and 5-fluorouracil 4g/96h. Results: 1) In 26 of the 30 patients (86.6%) suffering from pain, there were 20 complete pain relief responses (76.9%) and 6 partial responses (23.1%), for an overall response rate of 100%. In 13 patients suffering from sciatic pain and leg edema, there were 8 patients with CR (61.5%) and 5 patients with PR (38.5%). 2) Tumor regression: In all 30 patients, there were 16 CRs (53.3%), 11 PRs (36.7%) and 3 SDs (10%) and the overall response rate was 90%. Response duration: Median duration was 5 months and mean duration was 12.3 months with range 3 to 40 months. There were 12 patients with tumor progression after response to treatment. 3) Tumor marker SCC: In 28 patients having serum SCC measurement, there were 25 patients with SCC level > 1.5ng/ml (2.2-67.4ng/ml). Of the 25 patients, 23 patients' SCC decreased to normal level (82.2%) and 5 patients decresed but not to normal level (17.8%). 4) Survival: Up to date, 11 patients survived more than 1 year (36.7%), and 4 patients more than 2 years (13.3%) and 2 patients more than 3 years (6.7%). Complications: Less than grade III haematologic toxicity occurred in 36.7% (11 patients) and grade IV 6.7% (2 patients). There was a 6.7% gastrointestinal toxicities (2 patients) in the cases and 1 patient (3.3%) developed to grade II late bladder toxicity (chronic bleeding). Conclusion: 3DCRT and concurrent chemotherapy for recurrent carcinoma of the cervix are effective to a 100% subjective response and 90% tumor response. The complication does not increase while escalating the radiation dose. 3DCRT for isolated para-aortic lymph nodes metastases gets a superior effect to other site relapse. Patients with recurrence after definitive radiotherapy located within pelvis have no CR and the prognosis is not good.