Abstract: Objective: To explore the surgical options for treatment of cancerization relative to breast intraductal papilloma. Methods: Clinical data of 63 patients with intraductal papilloma were collected, arranged and analyzed during January 2000 to December 2004. Results: All the patients were performed surgical management. Two of the 63 patients were treated with quarter mastectomy; 12 of them were performed with quarter mastectomy plus axillary lymph node resection; 23 underwent modified radical mastectomy (Auchincloss); 5 underwent modified radical mastectomy (Patey) and 1 was conducted with radical mastectomy. In a post-operative pathological report, 43 cases were cancerization of intraductal papilloma (carcinoma in situ) and 20 cases were cancerization of intraductal papilloma with early stage invasion. All the excised margins were negative and no axillary node was involved. Conclusion: Cancerization associated with breast intraductal papilloma can be successfully managed with local extended lumpectomy for the affected duct and /or the lump and resection of the axillary lymph node is not always necessary.