周业琴, 谭榜宪. 116例宫颈癌综合治疗的临床观察[J]. 中国肿瘤临床, 2006, 33(2): 102-104.
引用本文: 周业琴, 谭榜宪. 116例宫颈癌综合治疗的临床观察[J]. 中国肿瘤临床, 2006, 33(2): 102-104.
Zhou Yeqin, Tan Bangxian. The Clinical Study on Combined Therapy of Uterine Cervix Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(2): 102-104.
Citation: Zhou Yeqin, Tan Bangxian. The Clinical Study on Combined Therapy of Uterine Cervix Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(2): 102-104.

116例宫颈癌综合治疗的临床观察

The Clinical Study on Combined Therapy of Uterine Cervix Cancer

  • 摘要: 目的:探讨宫颈癌综合治疗的合理选择及临床价值。方法:采用综合治疗方案治疗116例宫颈癌,对其治疗结果进行临床对比观察。结果:1)单纯手术组Ⅰb、Ⅱa、Ⅱb期3年生存率分别为87.5%、60.0%、50.0%。手术+术前放疗组Ⅰb、Ⅱa、Ⅱb期3年生存率分别为87.5%、85.7%、81.8%。手术+术后放疗组Ⅰb、Ⅱa、Ⅱb3年生存率分别为100%、75.0%、75.0%。放疗+化疗组Ⅲ、Ⅳ期患者的3年生存率分别为52.6%,0。各组生存率有显著性差异(P<0.01)。2)临床分期和术后盆腔淋巴结转移是影响预后的重要因素,术后盆腔淋巴结无转移者3年生存率为95.7%,盆腔淋巴结转移1~2枚者3年生存率为75.0%,盆腔淋巴结转移>2枚者3年生存率为56.3%。结论:宫颈癌综合治疗的近期疗效优于单纯手术,术前放疗能提高手术切除率,并不增加术后并发症。淋巴结转移枚数与宫颈癌的生存率相关,术后有不良预后因素者应加辅助治疗。

     

    Abstract: Objective: To explore the clinical value and rational choice for combined therapy of cervical cancer. Methods: A total of 116 patients have received the combined therapy. The prognostic factors and treatment results were analyzed. Results: 1) The 3-year survival rate of cervical cancer with stage Ⅰb, Ⅱa and Ⅱb, treated with surgery alone, was 87.5%, 60% and 50%, respectively. And the 3-year survial rate of cervical cancer with stage Ⅰb, Ⅱa, and Ⅱb, treated with preoperative radiotherapy and surgery, was 87.5%, 85.7% and 81.8%, and those with postoperative radiotherapy was 100%, 75% and 75% respectively. The 3-year survial rate of stage Ⅲ and Ⅳ cervical cancer with radiotherapy and chemotherapy was 52.6% and 0%, respectively. The difference of the four groups was statically significant. (P<0.01). 2) The clinical stages and postoperative pelvic lymph-node metastasis were the important prognostic factor for the patients with cervical cancer. The 3-year survival rate was 95.7% with no lymphatic metastasis, 75.9% with 1~2 positive nodes and 56.3% with more than 2 positive nodes. Conclusions: The near-term efficacy with combined therapy is better than that with surgery alone, the preoperative radiotherapy can raise the removal rate, but has little increase in the postoperative complications. The number of positive nodes in the pelvis relates to the survival rate. For the patients who had high-risk factor after the operation, adjuvant therapy should be given.

     

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