Abstract: Objective :To explore the curative effect of loop electrosurgical excision procedure(LEEP) therapy and concurrent elimination of HPV infection on cervical intraepithelial neoplasia (CIN). Methods :Ninety-eight cases with high-risk HPV infection and CIN I/II/III were confirmed with Thin-Prep liquid-based cytology test (TCT) and histology. The patients were treated with LEEP. TCT andhybrid capture II (HC-2) were conducted to screen for HPV three months later, and the patients withpositive results were examined by histology. Results : Seventy-four percent of CIN I cases tested nega-tive for HPV (49/66), and the HPV clearance rate was 4.5% (3/66). The rates of viral clearance andHPV persistent infection were as expected. CIN II/III had lower rates of viral clearance and higher ratesof HPV persistent infection, and statistical significance was clear. Conclusions :The presence of high-risk HPV infection is directly proportional to the pathological change of CIN, with CIN II/III havinghigher infection rates than CIN I. LEEP is an effective procedure for curing CIN I and can eliminateHPV infection. This procedure is not quite satisfactory for treatment of CIN II/III, so enlarged excisionof cervical tissue is essential. TCT and HC- 2 examination can estimate the therapeutic effect of LEEPon CIN and become a good method for making a prognosis for CIN.