Abstract: Objective: To investigate the impact and significance of VEGF-C and VEGFR-3 ex-pression in breast carcinoma lymph node metastasis. Methods: A total of 48 cases with primary breast cancer and 10 cases of adenosis and adenofibroma tissues were detected using S-P immunohistochemi-cal staining. Results: Among the 48 cases of breast cancer, the positive rate of VEGF-C and VEGFR-3was 70.83% and 87.50% respectively, but it was not expressed among the 10 cases of adenosis and adenofibroma. The positive rate of VEGF-C in the lymph-node metastasis group was significantly high-er than that of no lymph node metastasis group (92.59%:42.86%; P<0.01). With the increase of VEGF-Cprotein level, the number of VEGFR-3 positive lymphatic vessels was increased. The number of VEG-FR-3 positive lymphatic vessels in the lymph-node metastasis group was significantly higher than thatof the group with no lymph node metastasis (6.03:2.01; P<0.01). Conclusion: The expression of VEGF-Cin breast carcinoma is related with that of VEGF R- 3 positive lymphatic vessels and lymph node metas-tasis.