Abstract: Objective: To study the clinicopathologic characteristics and histogenesis of solid-pseudopapillary tumor (SPT) of the pancrea. Methods: The clinicopathologic data were reviewed in there patients with STP. Immunohistochemistry for a-AT、 Vim、 Syn、 EMA、 CK、 ER、 PR was performed inall the case using En Vision method. Results: All the patients were adolescent and young adult female,mean 28 years. The mean diameter of tumor was 9.6cm,all encapsulated.Histologic examination showed presence of solid sheets, pseudopapillary, in all of the cases. Hemorrhage, foam cell, 2 cases were posi-tive for a-AT, 3 cases expressed vimentin,1 case expressed Syn and PR.But negative for ER and EMA.Conclusion: SPT of pancreas is a distinct Clinicopathologic entity in young adult female patients rel-ertivty and that is a tumor with low malignant potential. Immunohistochemistry is very important in the diagnosis and differential diagnosis of SPT of the pancrea.