王凡, 黄强, 周丽英. 高聚生(SEC)联合手术放化疗治疗胶质瘤及其机制的探讨[J]. 中国肿瘤临床, 2006, 33(8): 445-448.
引用本文: 王凡, 黄强, 周丽英. 高聚生(SEC)联合手术放化疗治疗胶质瘤及其机制的探讨[J]. 中国肿瘤临床, 2006, 33(8): 445-448.
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Wang Fan, Huang Qiang, Zhou Liying. The Studies of SEC Therapy Combined with Radiochemotherapy on Glioma and Analysis of Treatment Mechanism[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(8): 445-448.
Citation: Wang Fan, Huang Qiang, Zhou Liying. The Studies of SEC Therapy Combined with Radiochemotherapy on Glioma and Analysis of Treatment Mechanism[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(8): 445-448.
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高聚生(SEC)联合手术放化疗治疗胶质瘤及其机制的探讨

The Studies of SEC Therapy Combined with Radiochemotherapy on Glioma and Analysis of Treatment Mechanism

    摘要
  • 摘要: 目的:观察高聚生(SEC)联合手术、放疗、化疗对胶质瘤的治疗效果及SEC促淋巴细胞诱生IL-2作用。方法:92例胶质瘤患者,均经手术切除。随机分为对照组、治疗A组(全身应用SEC)及治疗B组(局部应用经SEC活化的淋巴细胞),联合放疗、化疗,通过颅脑CT片观察疗效。采用免疫组化及RT-PCR测定SEC促淋巴细胞分泌IL-2作用。结果:对照组有效率为32.0%,治疗A组及治疗B组有效率分别为51.6%及63.6%。经SEC活化的淋巴细胞在作用第一天开始分泌IL-2,第3～5天达峰值。结论:SEC作为一种超抗原,与手术、放疗、化疗联合能明显提高临床疗效。被其活化的淋巴细胞能大量分泌IL-2。

     

    Abstract: Objective: To probe into the anti-glioma effects of SEC combined with surgery, radio-therapy and chemotherapy and to observe the effects releasing IL-2 of lymphocyte activated by SEC.Methods: A total of 92 patients suffering from glioma were randomly divided into control group, treat-ment group A and B and then the analytical results were observed through CT. IL-2 in lymphocyte ac-tivated by SEC was measured using immunohistochemistry and RT-PCR method. Results: Clinical ma-terials showed that the rate of effect (CR and PR) in the control group was 32%, while The effective-rate was 51.6% in treatment group A and 63.6% in the group B. The secreting activity of IL-2 of lym-phocyte activated by SEC reached peak at the third day and then decreased slowly at the 5 th and the 7 thday. Conclusion: SEC combined with surgical operation, radiotherapy and chemotherapy can raise the the treatment-effect in patient with glioma. The lymphocyte activated by SEC has obviously can release IL-2.

     

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