郭跃信. 老年食管癌加速超分割放射治疗的临床探讨[J]. 中国肿瘤临床, 2006, 33(7): 386-388.
引用本文: 郭跃信. 老年食管癌加速超分割放射治疗的临床探讨[J]. 中国肿瘤临床, 2006, 33(7): 386-388.
Guo Yue-xin. Clinical Investigation on the Effect and Complication of Accelerated Hyper-fractionation for Elderly Patients with Esophageal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(7): 386-388.
Citation: Guo Yue-xin. Clinical Investigation on the Effect and Complication of Accelerated Hyper-fractionation for Elderly Patients with Esophageal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(7): 386-388.

老年食管癌加速超分割放射治疗的临床探讨

Clinical Investigation on the Effect and Complication of Accelerated Hyper-fractionation for Elderly Patients with Esophageal Carcinoma

  • 摘要: 目的:探讨老年食管癌加速超分割放射治疗的疗效、毒副作用和并发症。方法:将96例患者随机分为常规治疗组(CF)和加速超分割治疗组(CAF)。CF组:每次1.8~2.0Gy,总剂量60~70Gy/30~35fx。CAF组:每天照射2次,每次1.5Gy,总剂量54Gy/3.5w,两组患者均用60Co-γ射线外照射。结果:两组患者均顺利完成了疗程,其1、3、5年生存率CF组分别为45.8%(22/48)、18.8%(9/48)、12.5%(6/48);CAF组分别为70.8%(34/48)、39.6%(19/48)和29.2%(14/48),CAF组疗效明显优于CF组(P<0.05)。毒副作用主要表现为放射性食管炎和放射性气管炎,但均无统计学差异。并发症中,早期以食管穿孔、食管出血为主要表现,晚期主要表现为食管缩窄、咯血及持续性咳嗽,两组相比无统计学意义。结论:CAF组患者能耐受根治性放疗;CAF组患者放疗的毒副作用及并发症较CF组明显,但两组发生率无统计学意义。

     

    Abstract: Objective: To investigate the result, toxic effect and complication of accelerated hyper-fractionation radiotherapy for elderly patients with esophageal carcinoma. Methods: From December 1990 to July 1992, 96 cases with esophageal carcinoma were enrolled in the study. They were dividedinto two groups by stratified randomization as follow: a) The patients in the conventional fractionation group (CF) received routine radiotherapy 60-70Gy/(30-35fx) and b) those in the group of continuously accelerated fractionation radiotherapy (CAF) received 54Gy/3.5w, 2fx/d. The same Cobalt 60 radiother-apy was used in both groups. Results: The radiation treatments were able to be complicated without any break. The survival rate of 1, 3 and 5 in the CF group was 45.8% (22/48), 18.8%(9/48) and 12.5% (6/48), and was 70.8% (34/48), 39.6% (19/48) and 29.2% (14/48) in the CAF group, respectively. The toxic effects were mainly radiation esophagitis and radiation tracheitis, but there was no significant dif-ference. The early complications were mainly esophageal bleeding and esophageal fistula, and the later complication were mainly esophageal stenosis, haemoptysis and continuous cough, but there was no sig-nificant difference, too. Conclusions: CAF can be tolerated by most patients with esophageal carcino-ma; the toxic effect and complication of CAF are more severe than that of CF, but there is no significant difference.

     

/

返回文章
返回