Abstract: Objective :To screen and clone the genes expressed differentially between thyroid car-cinoma and the paraneoplastic thyroid tissue, including papillary carcinoma of the thyroid (PTC) andundifferentiated carcinoma of the thyroid (UTC). Methods :Differentially expressed cDNA fragmentswere cloned and identified using differential display of mRNA, and then a homology search of the NCBIGenBank database was conducted. Results :Eight cDNA fragments were successfully cloned and identi-fied in NCBI GenBank. Those genes are possibly related to oncogenesis of thyroid carcinoma, especiallythe differentially expressed fragment homologous to LMAN1, which was detected in PTC and UTC. Conclusions :The differentially expressed fragments establish a favorable foundation for cloning genesrelated to thyroid carcinoma and continuing with their functional studies.