Abstract: Apigenin is a compound of plant flavonoid which has multi-biologic activity and phar-macological action, especially in the respect of anti-cancer activity. It can inhibit the proliferation, in-vasion and metastasis of the cancer cells, interfere with the signal transduction, induce apoptosis and anti-oxidization and so on. In the study we reviewed the progress in studies on anti-breast cancer ac-tion mechanism of Apigenin.