吴桂梅, 罗来敏, 王玉东, 张睿. 子宫内膜腺癌组织中COX-2与VEGF的表达及相关性研究[J]. 中国肿瘤临床, 2006, 33(12): 682-685.
引用本文: 吴桂梅, 罗来敏, 王玉东, 张睿. 子宫内膜腺癌组织中COX-2与VEGF的表达及相关性研究[J]. 中国肿瘤临床, 2006, 33(12): 682-685.
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Wu Guimei, Luo Laimin, Wang Yudong, Zhang Rong. The Correlation between COX-2 and VEGF Expression in Endometrial Adenocarcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(12): 682-685.
Citation: Wu Guimei, Luo Laimin, Wang Yudong, Zhang Rong. The Correlation between COX-2 and VEGF Expression in Endometrial Adenocarcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(12): 682-685.
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子宫内膜腺癌组织中COX-2与VEGF的表达及相关性研究

The Correlation between COX-2 and VEGF Expression in Endometrial Adenocarcinoma

    摘要
  • 摘要: 目的 :研究环氧合酶-2(CyclooxygenaseCOX-2)及血管内皮生长因子(VascularEndothelialGrowthFactorVEGF)在子宫内膜腺癌及复杂性增生病变组织中的表达,以探讨COX-2的表达与子宫内膜腺癌发生、发展的关系以及与VEGF之间的相关性。 方法 :应用逆转录聚合酶链反应(RT-PCR)技术,检测22例子宫内膜腺癌,10例复杂性增生子宫内膜,10例萎缩性子宫内膜组织中COX-2mRNA和VEGFmRNA的表达。 结果 :COX-2mRNA,VEGFmRNA在萎缩性、复杂性增生子宫内膜及子宫内膜腺癌中的相对含量分别为8.86±19.12、55.76±48.46、132.64±56.99和15.23±24.86、57.30±49.40、142.31±59.45。子宫内膜腺癌及复杂性增生子宫内膜COX-2mRNA,VEGFmRNA的相对含量显著高于萎缩性子宫内膜(P<0.001);子宫内膜腺癌COX-2mRNA,VEGFmRNA的相对含量高于复杂性增生子宫内膜(P<0.01)。且COX-2的表达与VEGF的表达呈正相关(r=0.959,P<0.01)。 结论 :COX-2、VEGF在子宫内膜腺癌组织中高表达,与其发生、发展有密切的关系,VEGF可能是COX-2促进子宫内膜腺癌形成、发展的主要机制之一。

     

    Abstract: Objective :To investigate the relationship between the expression of COX-2 mRNAand VEGF mRNA and the development of endometrial adenocarcinoma. Methods :Quantitative re-verse-transcription polymerase chain reaction (RT- PCR) was used to examine the levels of COX-2mRNA and VEGF mRNA in the following groups:10 cases with atrophic endometrium, 10 with com-plex endometrial hyperplasia and 22 with endometrial adenocarcinoma. Results :The relative amount ofCOX-2 mRNA and VEGF mRNA expressed in atrophic endometrium,complex endometrial hyperplasiaand endometrial adenocarcinoma were 8.86±19.12, 55.76±48.46, 132.64±56.99, and 15.23±24.86,57.30±49.40 and 142.31±59.45, respectively.The expression of these two genes in endometrial adeno-carcinoma and complex hyperplasia was significantly higher than in atrophic endometrium (P<0.001).The relative amount of COX-2 mRNA and VEGF mRNA in endometrial adenocarcinoma was signifi-cantly greater than in complex endometrial hyperplasia (P<0.01).COX-2 expression was positively cor-related with VEGF expression. Conclusion :High COX-2 and VEGF expression levels are detected inendometrial adenocarcinoma tissue.These two genes play an essential role in tumor development andgrowth.COX-2 may stimulate angiogenesis through VEGF up-regulation.

     

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