Abstract: Objective: To investigate the expression of oncogene AKT2 product, in human lung squamous cancer and adenocarcinoma tissue and its correlation with cell proliferation and metastasis. Methods: The expression of AKT2 protein and proliferating cell nuclear antigen (PCNA) in 80 cases of lung squamous cancer and adenocarcinoma tissue and 35 cases of non-cancerous lung disease were assessed using immunohistochemistry, and their correlations with clinicopathologic factors were statistically analyzed. Results: The total positive rate of AKT2 in lung squamous cancer and adenocarcinoma tissue (91.3%) was significantly higher than that of AKT2 in no-cancerous lung disease (5.7%)(P<0.05); In the group with and without lymph node metastasis. The positive rate was 100.0% and 80.6% respectively, the difference between them was significant (P<0.05). No significant correlation was found between positive AKT2 expression and age, gender, histologic type and tumor differentiation and TNM staging (P>0.05). PCNA labeling indexes in lung cancer tissue and non-cancerous lung disease was (52.45±26.14)% and (9.57±2.20)% (P<0.01) respectively. In lung squamous cancer and adenocarcinoma, total express of AKT2 protein positively correlated with PCNA high proliferation index (P<0.01). Conclusion: High expression of AKT2 may be related to the high proliferating activity and malignant behavior of lung squamous cancer and adenocarcinoma. AKT2 might play an important role in genesis and development of Lung cancer.