Abstract: Objective: To investigate the correlation between the E-cadherin expression and clinicopathological parameters, as well as prognosis of the patients with oral squamous cell carcinoma. Methods: The expression of the protein E-cadherin in the surgical specimens of 43 cases with oral squamous cell carcinoma was examined by SABC immunohistochemistry. Results: There was a significant correlation between the level of E- cadherin expression, tumor stage (P=0.024), invasive pattern (P=0.009) and lymph node metastasis (P=0.023). No correlation was found in the age (P=0.084), sex (P= 1.356) and differentiation (P=0.877). The Kaplan-Meier method demonstrated that the E-cadherin with the low expression had a significantly poorer prognosis compared to the cases with the high expression (P=0.0146). Conclusion: E-cadherin is an important indicator of clinical diagnosis and prognositic marker for oral SCC patients.