Abstract: Objective: To explore the molecular pathological characteristics of cancer of the cervix in women patients below 35, disclose certain factors for the unfavorable prognosis and to provide some useful targets for improving therapeutic effect. Methods: The pathological data of 64 patients with cancer of the cervix below 35, collected from June, 1995 to June, 2000 in our institution, were retrospectively analyzed as the study group, and the pathological data obtained from 90 cases with cancer of the cervix beyond 35 undergoing treatment during the same time were at random selected as the control group. Immunohistochemistry and quantified image analysis were used to synchronously detect differences in the protein expression of the survivin, p27, CD44v6, MMP-2 and TIMP-2 between the 2 groups. Results: The overall 5-year survival rate of the study group was 65.6% and was lower than that of the control group (84.4%). There was a significant difference (P<0.05). The expression of the survivin, MMP-2 and CD44v6 in the study group was much higher compared to that in the control group, but TIMP-2 was just on the contrary, with a higher expression in the control group (P<0.05), and there was no significant difference in the P27 expression between the 2 groups (P>0.05). Conclusions: The young women patients have a worse prognosis compared to the aged. Our study reveals that the survivin, MMP-2, TIMP-2 and CD44v6 have a correlation with this symptom. Improvement for prognosis of the young female patients with cancer of the cervix can be expected by the biomedical therapy targeting these molecular factors.