Abstract: Objective: To evaluate the effect of co-induction chemotherapy followed by 3-dimensional conformal radiation therapy (3DCRT) for elderly patients with locally advanced non-small-cell lung cancer. Methods: A retrospective analysis of 128 patients treated with 3DCRT in combination with the co-induction chemotherapy was conducted. All the 128 patients were 60 years or older. They were treated with radiation therapy alone (groupⅠ, 70 cases) or chemoradiotherapy (groupⅡ, 58 cases), respectively. Results: The overall response rate was 74.3% in groupⅠand was 82.8%in groupⅡ (P= 0.248). The 1-year overall survival rate was 41.4% in group Ⅰand was 56.9% in groupⅡ, respectively (P=0.081). There was no statistical difference in the overall response and the 1-year overall survival rate between the two groups. The 2-year overall survival rate was 27.2% in group Ⅰand was 44.8% in groupⅡ, respectively (P=0.037). There was a statistical difference between the two groups. Conclusion: The 3-DCRT with co-induction chemotherapy will be an optimal therapy and may extend the life span compared to simple radiotherapy, but further observation of the prostecdtive efficacy is needed.