Abstract:
Objective: To analyze clinicopathological characteristics, diagnosis and differential diagnosis of the hepatic angioleiomyolipoma (HAML). Methods: Two cases with the HAML were studied using light microscopy and immunohistochemistry, in combination with a review of literatures. Results: The tumors were composed of various amounts of three components: i.e. blood vessels, smooth muscle cells and adipose cells. Immunohistochemically, the smooth muscle cells were positive for HMB45, Desmin, Actin, the endothelial cells were positive for CD34 and the adipose cells were positive for S-100. Conclusion: A correct diagnosis of HAML might be difficult due to various growth patterns and cell types. Positiveness of the HMB45 in the smooth muscle cells is a key feature for HAML.