Abstract: Objective: To investigate clinical features and related prognostic factors of multiple primary gastric carcinomas (MPGC). Methods: The clinical data of 58 patients with MPGC, admitted in the Cancer Center of Zhongshan University from 1964 to 2004, were reviewed. Clinical pathological parameters, such as the gender, age, family history, rate of resectability, pathological types and adjacent viscera affected, as well as pTNM staging, were compared with homochronous single primary gastric carcinoma (HSPGC). Based on data from 1984, the Cox regression model was used to analyze prognosis of the patients. Results: There was no significant difference when comparing the clinicopathologic parameters of the MPGC and HSPGC (P>0.05). Based on data from 1984, there was a significant difference in the ratio of MPGC in the homochronous primary gastric carcinomas (HPGC) during a period of over 20 years, with the year 1984 as a middle demarcation (3.66% vs. 1.73%, P<0.05). The median survival time of the patients who received radical resection, palliative resection, by-pass, simple exploration or biopsy was 570 days, 303, 108 and 101 days, respectively. The median survival time (MST) for the cases with adjuvant chemotherapy after surgery was 494 days, while the MST for the cases receiving surgery alone without adjuvant chemotherapy was 218 days. Furthermore, the median survival time for the patients with stage Ⅰ, Ⅱ, Ⅲ and Ⅳ disease was 1204, 698, 264 and 139 days, respectively. Significant difference was observed in all of the above comparisons (P<0.05). Cox regression analysis demonstrated that the surgical method, pTNM stage, and combined therapy were independent prognostic factors for MPGC. Conclusion: There is no significant difference in clinical features between MPGC and HSPGC. Prognosis for patients with MPGC will improve only if early diagnosis and the curative resection rate are enhanced. Adjuvant chemotherapy is still necessary.