倪润洲, 杨磊, 肖明兵, 李峰, 陆翠华, 朱净. 血清HS-AFP GGT-Ⅱ对肝癌患者手术预后判断的价值[J]. 中国肿瘤临床, 2007, 34(4): 204-207.
引用本文: 倪润洲, 杨磊, 肖明兵, 李峰, 陆翠华, 朱净. 血清HS-AFP GGT-Ⅱ对肝癌患者手术预后判断的价值[J]. 中国肿瘤临床, 2007, 34(4): 204-207.
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Ni Runzhou, Yang Lei, Xiao Mingbing, Li Feng, Lu Cuihua, Zhu Jing. The Value of HS- AFP and GGT- Ⅱ for Judgment o the Prognosis of Patients Receiving Surgical Tr eatment for Hepatocellular Car cinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(4): 204-207.
Citation: Ni Runzhou, Yang Lei, Xiao Mingbing, Li Feng, Lu Cuihua, Zhu Jing. The Value of HS- AFP and GGT- Ⅱ for Judgment o the Prognosis of Patients Receiving Surgical Tr eatment for Hepatocellular Car cinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(4): 204-207.
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血清HS-AFP GGT-Ⅱ对肝癌患者手术预后判断的价值

The Value of HS- AFP and GGT- Ⅱ for Judgment o the Prognosis of Patients Receiving Surgical Tr eatment for Hepatocellular Car cinoma

    摘要
  • 摘要: 目的:探讨血清肝癌特异性甲胎蛋白(HS-AFP)和γ-谷氨酰转肽酶同工酶Ⅱ(GGT-Ⅱ)对原发性肝癌患者手术预后判断的临床价值。方法:对40例肝癌患者手术切除前后的血清HS-AFP、GGT-Ⅱ进行动态观察,并与患者的生存期进行对比分析。结果:40例肝癌患者术前HS-AFP﹑GGT-Ⅱ阳性率分别为57.5%和67.5%,联合检测阳性率为80.0%。术后发生复发转移者在HS-AFP和GGT-Ⅱ阳性组分别为90.9%和58.8%,而阴性组仅分别为20.7%和26.1%。术后HS-AFP和GGT-Ⅱ二者均为阳性的患者则均有复发转移。而术后二者均为阴性组患者复发转移率仅为9.5%。单因素分析显示术后HS-AFP和GGT-Ⅱ与患者预后有关。结论:术后血清HS-AFP﹑GGT-Ⅱ对肝癌患者手术后预后判断具有重要价值。

     

    Abstract: To investigate the clinical value of using hepatoma-specific alpha-fetoprotein (HS- AFP) and gamma-glutamyltransferase II (GGT- II) for predicting the outcome for patients who receive surgical treatment for hepatocellular carcinoma. Methods: Observation of the dynamic state of HS- AFP and GGT- Ⅱ in 40 patients with hepatoma, before and after excision, and a comparative study of the patients' survival time was conducted. Results: The preoperative positive rate of HS- AFP and GGT- Ⅱ was 57.5% and 67.5%, respectively, and the positive rate of the combined detection was 80.0%. After surgery, the recurrence and distant metastasis rate in the groups with positive HS- AFP and GGT- Ⅱ was 90.9% and 58.8%, respectively, while that in the groups with negative HS- AFP and GGT- Ⅱ was 20.7% and 26.1%, respectively. Recurrence and distant metastasis occurred in all cases with positive HS- AFP and GGT- Ⅱ, whereas after surgery the cases that were negative for both HS- AFP and GGT- Ⅱ accounted for only 9.5%. Univariate analysis revealed that the presence of HS-AFP and GGT- Ⅱ after surgery was related to the prognosis. Conclusion: After surgery, both the HS- AFP and GGT- Ⅱ are very useful for predicting the outcome for patients who receive surgical treatment for hepatocellular carcinoma.

     

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