吴长利, 张文岚, 畅继武, 赵津辉, 孙光, 韩瑞发. MDR1/P-gp在膀胱移行细胞癌中的表达及与Fas和Survivin蛋白表达的关系[J]. 中国肿瘤临床, 2007, 34(2): 82-85.
引用本文: 吴长利, 张文岚, 畅继武, 赵津辉, 孙光, 韩瑞发. MDR1/P-gp在膀胱移行细胞癌中的表达及与Fas和Survivin蛋白表达的关系[J]. 中国肿瘤临床, 2007, 34(2): 82-85.
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Wu Changli, Zhang Wenlan, Chang Jiwu, Zhai Jinhui, Sun Guang, Han Ruifa. Cor r elations between the Expr ession of MDR1/P- glycoprotein,Survivin and Fas in Tr ansitional Cell Car cinoma of the Bladder[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(2): 82-85.
Citation: Wu Changli, Zhang Wenlan, Chang Jiwu, Zhai Jinhui, Sun Guang, Han Ruifa. Cor r elations between the Expr ession of MDR1/P- glycoprotein,Survivin and Fas in Tr ansitional Cell Car cinoma of the Bladder[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(2): 82-85.
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MDR1/P-gp在膀胱移行细胞癌中的表达及与Fas和Survivin蛋白表达的关系

Cor r elations between the Expr ession of MDR1/P- glycoprotein,Survivin and Fas in Tr ansitional Cell Car cinoma of the Bladder

    摘要
  • 摘要: 目的:探讨膀胱移行细胞癌中MDR1基因(P-糖蛋白)与Fas、Survivin表达的相互关系及其与膀胱癌生物学行为的相关性。方法:应用免疫组织化学方法检测64例膀胱移行细胞癌和12例正常膀胱粘膜中P-GP、Fas、Survivin的表达。结果:膀胱移行细胞癌中P-GP、Survivin的表达阳性率高于正常粘膜,与膀胱癌的分级有关(P<0.01);而Fas在膀胱正常粘膜中表达高于移行细胞癌,差异有统计学意义(P<0.01)。复发性膀胱癌P-GP的阳性表达率高于初发膀胱癌(P<0.01)。膀胱移行细胞癌P-GP的表达与Fas呈负相关,而与Survivin表达无关。结论:膀胱移行细胞癌的MDR1(多药耐药基因)与Fas的表达密切相关,而与凋亡抑制蛋白Survivin的表达无关。本研究为采用MDR逆转剂或Fas干扰剂以增加膀胱移行细胞癌的化疗敏感性提供实验依据。

     

    Abstract: To explore the interrelation between expression of MDR1/P- glycoprotein, Fas and Survivin and to study the correlation between these expression levels and the biological behavior of transitional cell carcinoma of the bladder (TCCB). Methods: Immunohistochemistry was used to detect the expression of P- GP, Survivin and Fas in TCCB (n=64) and normal bladder mucosa (n=12). Results: The expression level of P- GP and Survivin in TCCB was higher than those levels found in normal bladder mucosa (P<0.01). The expression levels of P- GP and Survivin were strongly correlated with clinical stage (P<0.01). Fas was detected in 50% of the TCCB cases and in 100% of the normal bladder mucosa samples (P<0.01). P- GP expression in recurrent TCCB was higher than in primary TCCB (P<0.01). The expression of P- GP in TCCB had a negative correlation with that of Fas, but had no correlation with Survivin expression. Conclusions: Multiple drug resistance in TCCB is strongly correlated with the expression of P - GP and Fas, but not with Survivin expression. Our experimental evidence suggests that chemosensitivity may be increased by using MDR reversing agents or Fas interfering agents.

     

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