Abstract:
To investigate the expression and clinical significance of various drug resistance factors in lung cancer. Methods: Immunohistochemistry was used to determine the expression level of various tumor drug resistance factors in 66 samples of lung cancer. Results: a) The expression of P53, Pgp, MRP1, LRP, GST- πand TOPOⅡ1 was 74.24%, 45.45%, 51.52%, 81.82%, 81.82% and 83.33%, respectively. b) Different drug resistance factors had different expression characteristics in various lung cancers, specifically, there was a significant difference in the expression strength between the non- small cell lung cancer (NSCLC) and small- cell lung cancer (SCLC) (P<0.05). In addition, there was a significant difference between the strong positive expression and the different histological types,TNM stages, differentiation, lymph node metastasis and prognosis(P<0.05). c) The correlation analysis among the drug resistance factors showed that there was a significant correlation among P53, Pgp, MRP1 and GST- π, but the LRP and TOPOⅡ1 might be relatively independent drug resistance factors. Conclusion: The combination of expression of various drug resistance factors may predict the effect of chemotherapy and prognosis of lung cancer.