Abstract: Objective: To evaluate the therapeutic effect of and adverse reaction to Sodium Ibandronate (SI) in patients with osteodynia resulting from osseous metastasis from malignant tumors. Methods: Sixty-eight patients were randomly assigned to group A that received 4 mg SI i.v., and 73 patients were randomized into group B that received 60 mg PD i.v., using a randomized, double-blind clinical trial. The change in bone pain intensity and any side effects that occurred within three weeks were observed. Results: A total of 141 patients were enrolled in the study, with 136 cases suitable for efficacy appraisal. The effective rate was 72.3% (47/65) in group A and 63.4% (45/71) in group B. There was no significant difference between the 2 groups. The adverse effects were similar in group A and B. Conclusion: The SI injection, with a pronounced effect, can relieve bone pain caused by osseous metastasis of malignant tumor. The curative and adverse effects were similar to those found with pamidronate disodium.